GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7655841 | 1 | rs4394010 | chr4:129894649 | C4orf33 | chr4:130014829-130033842:+ | 0.6 | 9.47 | 1.26E-19 | Chronic obstructive pulmonary disease (moderate to severe) |
| THCA | cis | rs10862219 | 1 | rs4394894 | chr12:81464831 | ACSS3 | chr12:81471809-81649582:+ | 0.24 | 5.07 | 5.74E-7 | Neuroticism |
| THCA | cis | rs10862219 | 1 | rs4394895 | chr12:81464942 | ACSS3 | chr12:81471809-81649582:+ | 0.24 | 5.07 | 5.74E-7 | Neuroticism |
| THCA | cis | rs4332428 | 1 | rs4397735 | chr10:4965543 | AKR1C2 | chr10:4964715-5060207:- | 0.35 | 4.54 | 7.21E-6 | Height |
| THCA | cis | rs10043228 | 1 | rs4398671 | chr5:115557842 | COMMD10 | chr5:115420727-115628978:+ | 0.48 | 5.89 | 7.35E-9 | Asthma or chronic obstructive pulmonary disease |
| THCA | cis | rs7923609 | 1 | rs4399232 | chr10:64999490 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -6.64 | 8.31E-11 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs6726292 | 1 | rs4399760 | chr2:55157492 | RTN4 | chr2:55199329-55277734:- | -0.25 | -5.01 | 7.5E-7 | Obesity (extreme) |
| THCA | cis | rs7923609 | 1 | rs4400684 | chr10:65012687 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -6.73 | 4.85E-11 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs4404602 | 1 | rs4404602 | chr4:66470813 | EPHA5 | chr4:66185282-66535653:- | 0.2 | 3.46 | 0.00059 | HIV-1 viral setpoint |
| THCA | cis | rs13232179 | 1 | rs4404834 | chr7:151116702 | CRYGN | chr7:151127057-151137899:- | 0.15 | 3.67 | 0.000273 | Coronary heart disease |
| THCA | cis | rs4765219 | 1 | rs4405410 | chr12:124435788 | ZNF664 | chr12:124457670-124499967:+ | -0.17 | -5.03 | 6.81E-7 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs67073037 | 1 | rs4407214 | chr2:29118258 | TRMT61B | chr2:29072690-29093175:- | 0.39 | 6.83 | 2.55E-11 | Breast cancer (estrogen-receptor negative);Breast cancer |
| THCA | cis | rs59374417 | 1 | rs4407429 | chr3:119288897 | ADPRH | chr3:119298523-119308791:+ | 0.21 | 3.53 | 0.000458 | Vitiligo |
| THCA | cis | rs2834188 | 1 | rs4408796 | chr21:34698741 | IFNAR1 | chr21:34696734-34732126:+ | -0.22 | -5.3 | 1.82E-7 | Narcolepsy |
| THCA | cis | rs9815354 | 1 | rs4408846 | chr3:41753679 | ULK4 | chr3:41288091-42003660:- | 1.05 | 18.74 | 3.91E-59 | Diastolic blood pressure |